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[Sticky] Question for Eeva Tuppaainen - Lumpy Skin Disease: a challenge for three continents  

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Nadia Rumich
Active Member
Joined: 11 months ago
Posts: 7
08/12/2020 10:56 am  

What is your advice regarding the use of vaccines against LSD - homologous against sheeppox vaccines, with a special focus on efficacy and duration of protection? 

At the end of your presentation, you mentioned the responsibility that the scientific community has to provide decision makers with data. Could you elaborate a little on which data would be most useful, and how we can best make these data available to decision makers?

You highlighted the great transboundary spread of LSD over the past few years. Are there any particular steps that risk managers should be taking to prevent further incursions and spread to Europe?

Many of the challenges you described for LSD are very similar as for FMD (spread through animal movements, need to vaccinate many animals, challenges in implementing movement restrictions). Would an integrated approach to control therefore make sense (ie LSD and FMD together, perhaps with other diseases too), and is that happening in affected countries?

What is your advice regarding the use of vaccines against LSD - homologous against sheeppox vaccines, with a special focus on efficacy and duration of protection? 

What is the current status of international proficiency testing – esp. regarding reference labs organising the PTS, participation levels, results and main gaps? 

have there been economic analyses comparing the use of homologous and heterologous vaccines for LSD? Taking into account all these factors on side effects, effectiveness, cost of vaccine etc?

This topic was modified 11 months ago by Enrique

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tuppura
New Member
Joined: 11 months ago
Posts: 1
08/12/2020 1:33 pm  

Thank you very much for the excellent questions! 

Question 1 You highlighted the great transboundary spread of LSD over the past few years. Are there any particular steps that risk managers should be taking to prevent further incursions and spread to Europe?

 It is important to minimise the risk of transmission of LSD via cattle movements and trade. Prior to movement, there should be strict quarantine, health inspections and testing requirements in place . Unauthorized movements of cattle without any ID or health records are the highest risk but they are also probably the most difficult to control.

Mass vaccination is the only effective way to prevent the spread of the disease in Asia. It would include vaccination in affected and at risk regions. All animals to be moved should be vaccinated approximately 4 weeks before movements using effective vaccines.

I believe currently importation of cattle from LSD affected countries to EU Member States it is not possible/or highly regulated

Question 2 Many of the challenges you described for LSD are very similar as for FMD (spread through animal movements, need to vaccinate many animals, challenges in implementing movement restrictions). Would an integrated approach to control therefore make sense (ie LSD and FMD together, perhaps with other diseases too), and is that happening in affected countries?

I agree and would certainly recommend integrated control measures, that would save money and time!

Question 3 What is your advice regarding the use of vaccines against LSD - homologous against sheeppox vaccines, with a special focus on efficacy and duration of protection?

I would recommend the vaccines in the following order of best protection: 1. Homologous LSD vaccine. 2. Goatpox vaccine and 3. Sheeppox vaccines.

Studies on the actual the duration of the protection are ongoing but the manufacturers recommend annual vaccination. In case the sheeppox vaccines are used then prior to use a challenge trial should be carried out in controlled environment as the protection provided by the SPP vaccines for cattle against LSD  is not as good as for LSD and Goatpox vaccines.

Question 4. What is the current status of international proficiency testing – esp. regarding reference labs organising the PTS, participation levels, results and main gaps?

The Pirbright Institute, UK (OIE ref lab) and the Sciensano, Belgium (EU ref lab) organise proficiency Trials for LSD, sheeppox and goatpox. Third countries can also participate but the costs of the transport  of samples panels may need to be covered by the country. The contact persons are Dr Carrie Batten at Pirbright and Kris de Clercq at Sciensano. I’m not anymore personally involved with proficiency test trials but I understand that the ring trials are very popular (and also requirement of the Quality Assurance systems). Most of the national ref labs have a very good results. Pirbright and Sciensano staff will provide you with Information in more detail.

Question 5.  Have there been economic analyses comparing the use of homologous and heterologous vaccines for LSD? Taking into account all these factors on side effects, effectiveness, cost of vaccine etc?

As far as I‘m aware no comparative studies have been published, only on economic impact on LSD outbreaks in general level. While evaluating the side effects, man should bear in mind that the side effects caused by the LSD vaccine occur only when the animals are vaccinated for the first time, not anymore when annual booster vaccinations are given.


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ipekkeskin
New Member
Joined: 11 months ago
Posts: 2
14/12/2020 7:11 pm  

Thank you for your presentation Dr. Tuppaainen. You recommend the usage of LSD vaccines as homologous LSD vaccine, goatpox vaccine, and sheeppox vaccine. I would like to know if the endemic country doesn't have a homologous vaccine, application of goat or sheeppox vaccine 5 times or more provides the same immunologic response when we apply a homologous vaccine?


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Mostafa
New Member
Joined: 11 months ago
Posts: 2
15/12/2020 11:12 am  

Thans for your nice presentation. In Bangladesh, we are using Sheeppox vaccine too. Do you have any molecular study/information how it protects against LSD?


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Mostafa
New Member
Joined: 11 months ago
Posts: 2
15/12/2020 11:13 am  

Thans for your nice presentation. In Bangladesh, we are using Sheeppox vaccine too. Do you have any molecular study/information how it protects against LSD?


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