The California Department of Food and Agriculture (CDFA) in the United States manages and implements the Secure Food Supply (SFS) Program. The Program is envisioned as a “shield” that protects California agriculture during a Foreign Animal Disease or Notifiable Animal Disease outbreak and provides a pathway to economic survival for the industry through the permitted movement of animals and animal products. While the SFS Program is managed at the state level, it is implemented at the individual premises, rather than a compartment, level. The SFS Program is designed to allow businesses that are unaffected by the disease (i.e. negative for the disease) but located within a quarantine Control Area to maintain some business operations in order to maintain economic viability. The foundation of the Program is enhanced biosecurity that protects the premises and keeps disease out as well as ensures a safe product is leaving the premises. CDFA has been working on SFS planning for many years. During a recent, prolonged outbreak of virulent Newcastle disease in California, CDFA had the opportunity to operationalize the SFS Program. Over the two-year disease response, the Program had many successes, faced several challenges, and identified lessons learned to carry forward to enhance our state animal agricultural industry’s disease preparedness.